FIBRE AND CHRONIC INFLAMATION
Share
It has been postulated that low intake of dietary fibre is a risk factor for both local and systemic chronic inflammation [66,67]. The current dogma suggests that limited dietary fibre intake stymies the establishment and maintenance of a healthy, viable and diverse colonic microbiota that, in turn, limits the local production of SCFAs, including butyrate. Signalling pathways that implicate nuclear factor kappa-B (NF-ĸB) and inhibition of deacetylase influence inflammatory processes both locally (including gut-wall leakiness and colonic inflammation in patients with inflammatory bowel disease [68]) and systemically, and both are likely influenced by levels of butyrate within the colon [66]. Furthermore, butyrate may improve oxidative stress within the colon through effects on gene expression implicated in glutathione and uric acid metabolism [69]. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7589116/#sec5-nutrients-12-03209title (5.5 CHRONIC INFLAMATION)